This post contains major spoilers of the story.
Big boss Dexter

He took V for a spin and explained his plan to her.
After V had completed the first part of the plan, she met up with Jackie.
V and Jackie wanted to get a special robot from the Maelstroms.
On their way out they were attacked by soldiers of the Militech megacorporation. V and Jackie were able to overpower the soldiers with ease. With the robot in their luggage, they made their way to Dexter.
Not only Dexter was there, but also the Netrunner T-Bug, who had helped them out of trouble several times before.

Together they they went through the last steps of the planned big heist at the Konpeki Plaza Hotel. Their target was an experimental biochip.
At the Konpeki Plaza
V: "Are you ready?"
Jackie: "I've never been as ready as I am now. Let's rock."
Everything went well at first. But after the two witnessed a murder, everything that could go wrong, went wrong.
They managed to escape with the chip, however they had to pay a high price.
T-Bug died when she opened the locked door on their escape. Jackie died on the way to the refuge, another hotel.
With empty eyes and covered in blood, she looked in the mirror of the hotel room.
She smashed it out of anger.
When she came back from the bathroom, Dexter presented her with a nasty surprise. Without warning, he snuffed out her light. At least that's what he thought.
A bodyguard she came across during the heist reluctantly helped her out. He drove her to the Ripperdoc. But the journey was not without incident.
Viktor, the Ripperdoc, was able to patch her up.
Unfortunately, he still had very bad news for her. The biochip she had to connect to, or more precisely, what's on it, is in the process of erasing her consciousness piece by piece. It's the digitized soul of Johnny Silverhand.
